Prof. Dr. David Reginald Bundle

Profile

Academic positionFull Professor
Research fieldsNatural Product Chemistry,Biochemistry
KeywordsCarbohydrate protein interactions, Mutivalency, Conjugate vaccines

Current contact address

CountryCanada
CityEdmonton
InstitutionUniversity of Alberta
InstituteDepartment of Chemistry, Alberta Ingenuity Centre for Carbohydrate Research

Host during sponsorship

Prof. Dr. Thomas PetersInstitut für Chemie, Universität zu Lübeck, Lübeck
Prof. Dr. Bernd MeyerInstitut für Organische Chemie, Universität Hamburg, Hamburg
Start of initial sponsorship01/02/2006

Programme(s)

2005Humboldt Research Award Programme

Nominator's project description

Prof. David R. Bundle is working on structural and functional aspects during the immune response to carbohydrates. He has been among the first to characterize oligosaccharide / antibody complexes at an atomic level using diverse experimental techniques. Using this knowledge he recently designed and synthesized high affinity carbohydrate ligands to bacterial toxins to assist in detoxification. During the research stay in Germany he investigates ligand protein interactions employing a new NMR technique, Saturation Transfer Difference spectroscopy.